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在Condoliase注射后,对腰椎间盘的患者的核脉动组织进行基因组学分析

Yuka Minamisawa¹, Taiichi Shirogane², Ippei Watanabe²

¹Central Research Laboratories Seikagaku Corporation Tokyo Japan.

|April 5, 2024

概括

康多利阿斯有效降解脊柱中的氏丁硫酸盐,即使在治疗腰椎椎间盘之后患者的症状仍然存在. 组织学分析证实了酶的作用,而不会损害周围的组织.

科学领域:

生物化学生物化学
整形外科整形外科整形外科
历史学历史学历史学

背景情况:

腰椎间盘 (LDH) 往往用康多利酶治疗,这是一个向脊椎间盘 (IVD) 中的地硫酸 (CS) 酶.
治疗疗效不是普遍的,一些患者经历了持续的症状,尽管康多利阿斯的管理.
这项研究研究了在不响应的LDH病例中对孔多利酶的组织学影响.

研究的目的:

从组织学上分析LDH患者的腰椎间盘组织,这些患者没有对康多利治疗做出反应.
为了证实孔多利酶在人细胞核中对氏丁硫酸盐的体内作用.
评估康多利酶在细胞和周围组织活力方面的安全性.

主要方法:

从12名接受手术的LDH患者的腰椎间盘组织的组织学分析.
两个组:6名患者在全内镜脊柱手术 (FESS) 之前接受了康多利酶,6名患者没有.
使用抗-CS抗体检测CS降解的免疫组织化学.

主要成果:

在接受康多利酶的患者的细胞核中观察到大量的二丁硫酸盐,这表明了酶活性.
反-CS抗体证实了康多利酶接受者的CS降解,即使在不响应的情况下.
两组之间没有发现细胞外矩阵的组织学差异,这表明特定的CS向.

结论:

在人体IVD的细胞核中,Condoliase能够成功地降解胆二酸盐,无论治疗结果如何.
该酶的作用是特定于CS的,没有观察到软质细胞或邻近组织的亡.
这些发现支持condoliase在LDH治疗中的作用机制和安全概况.

关键词:

化学核聚变的化学核聚变.顺德里二硫酸盐顺德里二硫酸盐在Condoliase中使用.免疫组织化学免疫组织化学腰椎椎间盘的发生

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