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Updated: Jun 29, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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蒂安1介导的不适应性可塑性是底层的吗啡耐受性和过敏症的基础

Changqun Yao1, Xing Fang2, Qin Ru2,3

  • 1Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35025, USA.

Brain : a journal of neurology
|April 5, 2024
PubMed
概括

吗啡使用会导致疼痛耐受性和通过脊髓中的Tiam1引起的过敏症. 抑制Tiam1信号传递可能会减少这些副作用,从而允许长时间的疼痛管理.

关键词:
慢性疼痛管理 慢性疼痛管理对阿片类药物的耐受性由阿片类药物诱导的过敏症.突触性可塑性 突触性可塑性这就是TIAO1的意义.

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