在敏感个体中对的亚临床免疫反应 - 一项剂量反应研究
Michael Wennervaldt1, Helen Vaher2, Malin G Ahlström1
1Department of Dermatology and Allergy, National Allergy Research Centre, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.
Contact dermatitis
|April 5, 2024
概括
尼克尔过敏仍然存在,尽管有相关规定. 即使低剂量的暴露也会在敏感皮肤中引发免疫反应,这表明目前的欧洲限制可能无法完全保护消费者.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 过敏是欧洲普遍存在的问题,影响了14.5%的成年人.
- 目前的法规旨在限制消费品中的释放,但过敏的发病率仍然很高.
研究的目的:
- 在敏感皮肤中评估对低剂量暴露的免疫反应.
- 评估消费品中的现有监管限制的充分性.
主要方法:
- 用不同硫酸盐度 (0.2370μg/cm2) 对过敏和健康个体进行贴片测试.
- 临床反应和皮肤活检的分析,用于转录的免疫形状,使用Nanostring nCounter和qPCR.
主要成果:
- 15%的过敏参与者对规定的低剂量 (0.2/0.5μg/cm2) 产生了临床反应.
- 尼克尔再暴露诱导免疫激活,具有显著的基因上调 (81个基因),无论临床反应.
- 即使在0.2μg/cm2下,101个与免疫相关的基因在没有明显湿疹的敏感皮肤中也被差异地表达.
结论:
- 皮肤中的局部免疫记忆可以在当前的监管范围内被剂量激活.
- 调查结果表明,欧洲法规可能无法充分保护消费者免受低剂量暴露的不良反应.
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