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患者特征和嗅觉敏感性对Trigger Odorants在Parosmia和Phantosmia中的比较
Rumi Sekine1,2, Anna Kristina Hernandez1,3,4, Clara Overbeck1
1Smell & Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
The Laryngoscope
|April 5, 2024
概括
患有帕洛斯米亚和斯米亚的患者具有不同的特征. 所有组都对特定的触发性气味表现出更高的敏感性,这表明对理解嗅觉功能障碍的潜在影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 嗅觉研究 嗅觉研究
背景情况:
- 定性嗅觉功能障碍 (qualOD) 包含了诸如帕罗斯米亚和斯米亚之类的疾病.
- 了解这些疾病的独特特征对于诊断和管理至关重要.
研究的目的:
- 为了描述患有 qualOD 的患者,特别是 parosmia 和 phantosmia.
- 为了研究受影响个体对已知parosmia触发物的嗅觉敏感性.
主要方法:
- 研究包括年龄≥18岁的成年人,分为量化嗅觉功能障碍 (OD) 单独,parosmia和phantosmia组.
- 数据包括人口统计,嗅觉测试 (嗅探棒),问卷和触发性气味值测试 (2-furfurylthiol, 2,6-nonadienal).
主要成果:
- 帕洛斯米亚患者是年轻的女性,往往病毒后OD持续时间较短,并经历了更严重的症状.
- 幻影症患者年龄较大,具有较长的异常性OD持续时间,并经历了不太严重的症状.
- 与乙醇 (PEA) 相比,所有组对触发气味 (FFT,Nonadienal) 的嗅觉敏感性都显著增加.
结论:
- 帕洛斯米亚和斯米亚代表着独特的嗅觉障碍,具有独特的患者个人资料.
- 对触发气味的高度敏感性要求进一步调查帕洛斯米亚的病理生理学和临床影响.
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