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IRE1α识别了霍乱毒素中的结构动机,以激活未折叠的蛋白质反应

Mariska S Simpson1,2, Heidi De Luca1, Sarah Cauthorn1,3

  • 1Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston MA, USA.

The Journal of cell biology
|April 5, 2024
PubMed
概括

霍乱毒素 (CTx) 通过与特定的展开动机结合来激活内网膜传感器 IRE1α. 这种相互作用触发了展开的蛋白质反应 (UPR),并增强了细胞毒性.

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