异常的大脑三重网络在2型糖尿病中有效的连接模式
Yujie Zhang1, Xiao Yin2, Yu-Chen Chen1
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing, 210006, China.
概括
2型糖尿病 (T2DM) 患者表现出大脑网络连接的改变,影响认知功能. 这些发现揭示了与T2DM相关的认知衰退背后的神经机制.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 与认知障碍有关.
- 异常的大脑功能连接性与T2DM相关的认知缺陷有关.
研究的目的:
- 研究T2DM患者的三重网络有效连接模式.
- 检查默认模式网络 (DMN),突出网络 (SN) 和执行控制网络 (ECN) 之间的连接.
- 与认知衰退和临床参数相关联连接性改变.
主要方法:
- 招募了92名T2DM患者和98名健康对照 (HC).
- 使用休息状态功能磁共振成像 (rs-fMRI) 和光谱动态因果建模 (spDCM).
- 通过使用关键大脑区域,分析了DMN,SN和ECN内的有效连接.
主要成果:
- 与HCs相比,T2DM患者在三重网络内表现出改变的有效连接性.
- 糖尿病持续时间与特定的r-LPFC与mPFC连接有负相关性.
- 身体质量指数 (BMI) 与特定的l-LPFC与l-AINS连接性正相关.
结论:
- 在T2DM的三重网络模型中存在异常有效的连接模式.
- 研究结果提供了对T2DM认知功能障碍的神经学基础的见解.
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