长期使用克洛米芬在男性巨乳腺瘤中,持续患有阴性双胞胎症
Matheo A M Stumpf1, Stefano A Galliano2, Cristina B F Bueno3
1Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School Hospital, São Paulo, Brazil. matheoaugusto@hotmail.com.
Endocrine
|April 5, 2024
概括
克洛米芬酸盐 (CC) 有效地恢复了男性的丸激素水平 巨乳腺瘤和阴道腺缩症. 这项研究表明,CC是一种安全的,长期治疗选择,用于管理这些患者的持续性阴道腺缩症.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
背景情况:
- 在患有巨乳腺瘤的男性中,即使在正常化了益生菌度后,也可能发生持续性性阴性腺.
- 替代疗法是标准的,但克洛米芬酸盐 (CC) 是一种非标签的选择,特别是对于生育问题.
研究的目的:
- 为了评估克洛米芬酸盐 (CC) 在恢复雄性腺轴的有效性,在男性与巨乳细胞瘤.
- 为了评估CC的安全性,作为长期治疗持续性阴道腺缩症在这个人群.
主要方法:
- 对10名患有巨乳腺瘤和持续性阴性腺瘤的男性进行了回顾性研究,他们接受了cabergoline.
- 所有患者都接受了50毫克/天克洛米芬酸盐 (CC) 的初始剂量.
主要成果:
- 在平均3.2年的CC疗程期间,水平显著增加 (p=0.027).
- 80%的患者有反应,维持丸激素在300ng/dL以上;瘤大小保持稳定.
- 在CC治疗期间没有报告任何不良反应或安全问题.
结论:
- 克洛米芬酸盐 (CC) 是一种安全有效的治疗方法,用于治疗患有巨细胞巨瘤的男性持续性阴性双胞胎症.
- 在这种患者群体中,CC提供了一种可行的治疗选择,用于管理这种患者群体的阴道腺症.
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