系统性红斑狼患者的非甲状腺疾病综合征:与疾病炎症活动的关系
Xue Meng1, Ang Lv2, Mulin Tang1
1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Clinical rheumatology
|April 5, 2024
概括
非甲状腺疾病综合征 (NTIS) 在全身性红斑狼 (SLE) 患者中更为普遍. 像SLEDAI,SII和ESR这样的高炎症标志物是SLE患者NTIS的关键风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 非甲状腺疾病综合征 (NTIS) 是一种疾病,其特点是甲状腺激素水平发生变化,而没有固有的甲状腺疾病.
- 系统性红斑狼 (SLE) 是一种具有复杂系统表现的慢性自身免疫性疾病.
研究的目的:
- 调查与诊断为SLE的患者NTIS发展相关的风险因素.
- 为了比较在SLE患者中NTIS的患病率与健康的对照组.
主要方法:
- 一项追溯分析,涉及517名SLE患者和1034名年龄和性别匹配的健康对照.
- 在SLE患者和对照人群之间比较NTIS患病率.
- 对患有NTIS的SLE患者的临床和实验室特征的分析.
- 后勤回归分析以确定SLE中NTIS的独立风险因素.
主要成果:
- 与对照组 (1%) 相比,SLE患者的NTIS患病率明显高 (39.7%).
- 患有NTIS的SLE患者表现出较高水平的炎症标志物 (SLEDAI,SII,ESR),中性粒细胞,肝酶,损伤标志物,以及更高的器官缺陷发病率.
- NTIS患者的血红蛋白,淋巴细胞,血小板,血清白蛋白和补充剂水平较低,狼持续时间较短,疾病修饰性抗风湿药物 (DMARD) 的使用较低.
- 增加的SLEDAI,SII,ESR和肝功能不全被确定为SLE中NTIS的独立风险因素.
- 治疗DMARDs已经成为一种独立的防护因子,防止NTIS.
结论:
- 炎症活动在SLE患者中NTIS的发展中起着重要作用.
- 关键的炎症标志物,包括SLEDAI,SII和ESR,独立地与SLE中NTIS风险增加有关.
- 了解这些风险因素可以有助于在SLE患者中管理和预防NTIS.
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