在骨科瘤学中的功能性结果测量趋势
David Le1, Kelsey Martin2, Sean C Clark3
1University of Washington Medical Center, Seattle, Washington, USA.
概括
骨科瘤学研究很少使用功能性结果指标,肌肉骨瘤学会 (MSTS) 评分是最常见的. 患者报告结果测量信息系统 (PROMIS) 显示了日益增长的趋势.
科学领域:
- 整形瘤学 整形瘤学
- 肌肉骨研究 研究
- 临床结果评估评估.
背景情况:
- 功能性结果测量对于评估骨科瘤学治疗疗效至关重要.
- 目前的文献表明,与其他子专业相比,骨科瘤学中这些措施的采用率较低.
- 强调瘤和生存结果可能会影响选择结果措施.
研究的目的:
- 在骨科瘤学研究中使用功能性结果测量方法的趋势.
- 分析11年期间使用的结果指标的类型和频率.
- 为了比较不同功能成果指标的采用率.
主要方法:
- 2011年至2021年间在五个主要的骨科瘤学期刊上发表的文章的系统综述.
- 数据提取包括功能结果指标,研究日期,设计,主题和证据水平.
- 分析了5968篇以肌肉骨瘤为重点的文章,其中293篇符合纳入标准.
主要成果:
- 只有4.9%的审查文章包含了功能结果指标.
- 肌肉骨瘤学会 (MSTS) 评分是最普遍的 (61.1%),其次是多伦多极端救援 (TESS) 评分 (14.0%).
- 患者报告结果测量信息系统 (PROMIS) 显示每年显著增加 (1.2%),而MSTS使用率下降 (0.7%).
结论:
- 功能性结果测量在骨科瘤学研究中未得到充分利用.
- 虽然MSTS仍然占主导地位,但PROMIS正在成为关键的患者衍生结果衡量标准.
- 未来的研究应该更全面地探索以患者为中心的结果.
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