高度敏感的候选人即使避免了捐赠者特异性抗体,仍然面临微血管炎症的风险:一项匹配的队列研究

Amogh Agrawal1, Suryanarayanan Balakrishnan2, Manish J Gandhi3

  • 1Department of Transplant Surgery, William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN.

Transplantation
|April 5, 2024
PubMed
概括

没有捐赠者特异性抗体 (DSA) 的高度敏感的移植接受者显示出微血管炎症 (MVI) 的高发病率. 这种MVI可以持续和进展,甚至在没有可检测的DSA的情况下也会影响移植结果.

相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
68.2K
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
626
Cross-reactivity00:42

Cross-reactivity

Overview
31.1K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
489
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
366