抑制病态酸矿化:对疾病进展的影响
Yarden Nahmias1, Gabriel Yazbek Grobman1, Netta Vidavsky1,2
1Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
ACS applied materials & interfaces
|April 5, 2024
概括
像氧酸盐 (HA) 这样的病理性化与侵袭性乳腺癌有关. 抑制HA形成可能会意外地促进瘤生长,无形酸盐 (ACP) 对癌细胞表现出多种影响.
科学领域:
- 生物矿物化 生物矿物化
- 癌症生物学 癌症生物学
- 材料科学 材料科学 材料科学
背景情况:
- 病理性化,特别是酸微化 (MCs),在早期乳腺癌中很普遍.
- 氧酸盐 (HA) 是一种关键的MC成分,在瘤微环境中结晶,与侵袭性瘤和不良预后有关.
- 在体外,HA可以触发瘤发生.
研究的目的:
- 研究添加剂对HA结晶和抑制的影响.
- 评估癌前乳腺细胞对在添加剂存在时形成的矿物质的反应.
- 评估聚酸和聚烯酸 (PAA) 作为潜在的HA抑制剂.
主要方法:
- 模拟瘤微环境液体用于HA结晶.
- 评估了通过聚酸和PAA的HA抑制.
- 暴露于各种HA和无形酸 (ACP) 矿物质形式 (颗粒与聚合物) 的癌前乳腺细胞.
主要成果:
- 非静脉测量HA结晶,具有类似块的形态,模仿乳腺癌MCs.
- 通过形成球形的ACP粒子,PAA有效地抑制了HA.
- 细胞增殖反应因矿物阶段 (HA 与 ACP) 和聚合状态 (颗粒与聚合物) 而有所不同.
- 瘤源性影响的顺序是:HA颗粒 < HA聚合物 < ACP颗粒 < ACP聚合物.
结论:
- 矿物阶段,结晶性,形态和聚合状态影响细胞对化的反应.
- 抑制HA的副产品可能会加剧疾病的进展.
- 了解瘤微环境中的矿物细胞相互作用对于癌症预后至关重要.
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