综合饮食抗氧化剂指数与NHANES 2011-2014年美国老年人的认知功能之间的关联
Jiesheng Mao1, Haoxiang Hu1, Yunhan Zhao1
1Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou People's Hospital, Zhejiang, China.
Journal of Alzheimer's disease : JAD
|April 5, 2024
概括
更高的复合饮食抗氧化剂指数 (CDAI) 摄入量与老年人更好的认知功能有关. 保持适当的CDAI可能会支持大脑健康,并防止认知能力下降.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 认知神经科学 认知神经科学
背景情况:
- 富含抗氧化剂的饮食被认为有潜力保护老年人群的认知功能.
- 需要全面的饮食评估工具来准确测量抗氧化剂摄入量.
研究的目的:
- 研究复合饮食抗氧化剂指数 (CDAI) 与老年人的认知表现之间的关联.
- 评估一种新的饮食抗氧化剂摄入量指数与各种认知领域之间的关系.
主要方法:
- 从NHANES 2011-2014对2,456名参与者 (≥60岁) 的横截面分析.
- 使用六种关键矿物质和维生素 (,,,维生素A,C和E) 计算的CDAI.
- 认知功能使用CERAD单词学习,动物流利性测试 (AFT),数字符号替换测试 (DSST) 和复合认知z-score进行评估.
主要成果:
- 增加的CDAI与全球认知功能和特定认知领域正相关 (p <0.05) 经过对混因素进行调整后.
- 这种关联在中风患者中更为强烈 (p对相互作用<0.05).
- 对于CERAD,AFT和复合z-score观察到和效应;对于DSST发现了一个反转的U形关系.
结论:
- 较高的CDAI水平与老年人的认知功能显著提高有关.
- 保持最佳的CDAI可能是保护老年人认知健康的有益策略.
- 通过CDAI测量的饮食中抗氧化剂摄入量,在认知健康中起作用.
更多相关视频
06:58Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
7.3K
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
14.9K
相关概念视频
01:30Cognitive Development During Adulthood
96
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
96
01:26Aging
49
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
49
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
122
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
122