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齐莫桑和脂多聚糖化物降低了小外周器官中神经元氧化合成酶的基因表达.

Maki Takahashi¹, Tomohisa Ishida¹, Sakirul Khan²

¹Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.

Veterinary immunology and immunopathology

|April 5, 2024

概括

致病性挑战降低了小的神经氧化合成酶 (nNOS) 表达. 这种减少会影响食物摄入量,体温和消化功能,突出显示nNOSOS.

关键词:

一个漂亮的小.皮质类固醇胺的皮质.脂聚糖类糖化物脂聚糖类糖化物氧化氧化是什么?氧化合成酶是一种氧化合成酶.在Zymosanosan中,我们可以看到.

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科学领域:

动物生理学动物生理学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

氧化 (NO) 是一种关键的信号分子,由氧化合成酶 (NOS) 合成.
在病原性挑战期间,诱导性NOS (iNOS) 的上调,但感染期间鸟类中神经元NOS (nNOS) 和内皮NOS (eNOS) 的作用尚不清楚.

研究的目的:

为了研究齐莫桑和脂多糖 (LPS) 对 (Gallus gallus) 的NOS表达的影响.
为了确定NOS抑制对小生理和行为参数的影响.

主要方法:

内注射 (IP) 齐莫桑和LPS在小.
在各种器官中分析NOS mRNA表达的分析.
使用NOS抑制剂 (NG-nitro-L-arginine甲基和7-nitroindazole) 并评估食物摄入量,克洛亚克温度和料通道.

主要成果:

齐莫桑和LPS诱导了iNOS mRNA的表达.
在胰腺中,LPS增加了eNOS mRNA的表达,而zymosan没有影响.
这两种病原体都在肺,心脏,脏和胰腺中减少了nNOS mRNA的表达.
抑制NOS导致食物摄入量降低,克洛亚克温度降低和料通过.

结论:

真菌和细菌感染降低了鸟类中的nNOS表达.
减少nNOS表达与食物摄入,体温调节和消化过程受损有关.
这些发现表明,nNOS在禽类感染期间维持平衡中起着重要作用.