周围炎症与euthymic双极性患者的悲伤识别受损有关
Chih-Yu Chang1, Hui Hua Chang2, Cheng Ying Wu3
1Department of Medicine, College of Medicine, National Cheng Kung University, Taiwan.
Journal of psychiatric research
|April 5, 2024
概括
炎症,特别是TNF-α的升高,会损害双相情感障碍 (BD) 患者的悲伤识别能力. 这一发现突出了炎症.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 炎症会对健康个体的认知功能产生负面影响,也会影响像双相情感障碍 (BD) 这样的精神疾病.
- 情绪识别是社会认知的一个关键方面,可能受到炎症的影响.
- 在BD中,促炎性细胞因子和情绪识别之间的关系需要进一步研究.
研究的目的:
- 为了检查促炎性细胞因子和情绪识别之间的关联,euthymic BD患者和健康对照 (HCs).
- 确定BD患者悲伤识别准确性的预测因素.
主要方法:
- 招募了44名高血压BD患者和40名HC患者.
- 测量的炎症标志物:高灵敏度C反应蛋白 (hs-CRP),IL-6 (IL-6) 和TNF-α.
- 评估认知功能 (WCST,CPT) 和情绪识别 (DANVA-2-TW).
主要成果:
- 与HCs相比,瘤缩因子-α (TNF-α) 在euthymic BD患者中较高.
- 在BD患者中,TNF-α的升高与悲伤识别精度的降低相关.
- 即使在控制神经认知后,TNF-α也独立地预测了euthymic BD患者的悲伤识别准确性.
结论:
- 增加的TNF-α,表明炎症加剧,独立地预测BD患者的悲伤识别受损.
- 这表明TNF-α对悲伤识别有直接影响.
- 慢性炎症可能会增加易感性BD患者对抑郁症的脆弱性.
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