尿路稀土元素与肝功能之间的相关性在南宁35-74岁的庄族人群中
Xingxi Luo1, Liling Wei1, Shun Liu2
1Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
概括
这项研究发现,与五种稀土元素 (REEs) 的同时暴露与成人肝功能标志物的改变有关. 暴露的增加与更高的ALP和AST水平以及更低的DBIL水平有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生化学
背景情况:
- 动物研究表明,稀土元素 (REEs) 可以导致肝脏损伤.
- 基于人口的证据将REEs与肝功能联系在一起是有限的.
- 这项研究通过检查尿液和肝功能中的REEs来解决这个差距.
研究的目的:
- 在中国人群中研究尿液中REEs度与肝功能之间的关系.
- 评估个人和共同暴露在REEs对肝功能标志物的影响.
主要方法:
- 在中国南宁,对1024名参与者的横截面研究.
- 感应合血质谱仪 (ICP-MS) 用于检测尿液中的12个REEs.
- 用于分析的多重线性回归,WQS回归和BKMR模型.
主要成果:
- 在超过60%的参与者中检测到五个REE (La,Ce,Pr,Nd,Dy).
- 同时暴露于这五种REEs与血清ALP和AST正相关.
- 同时暴露与血清DBIL负相关,在La,Ce和Dy之间观察到相互作用.
结论:
- 同时暴露于五种特定的REEs与肝功能改变有关.
- 血清ALP和AST的升高,以及在REE同时暴露时观察到的DBIL降低.
- 这些发现突出了REE暴露对一般人群肝脏健康的潜在风险.
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