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多发性硬化症中残疾,运动和认知表现的结构和功能相关性:专注于白球 (globus pallidus)

Francesco Romanò¹, Paola Valsasina¹, Elisabetta Pagani¹

¹Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Multiple sclerosis and related disorders

|April 5, 2024

概括

多发性硬化症 (MS) 患者表现出改变的状球 (GP) 功能,而不是结构. 在GP中增加的铁积累与残疾相关,功能连接性的变化反映了基底腺节网络通信受损.

科学领域:

神经成像是一种神经成像.
神经学神经学
放射学放射学是一门学科.

背景情况:

多发性硬化症 (MS) 是一种影响中枢神经系统的脱髓化疾病.
白球体 (GP) 是基底的关键组成部分,在运动控制和认知功能中起着至关重要的作用.
了解MS中GP的结构和功能变化对于评估疾病影响至关重要.

研究的目的:

在患有多发性硬化症 (pwMS) 的人群中研究外部 (GPe) 和内部 (GPi) 全球的结构和功能变化.
将这些变化与健康对照 (HC) 进行比较.
为了将GP变化与临床残疾,运动和认知障碍相关联.

主要方法:

60名pwMS和30名HC接受了3.0TMRI,包括扩散张力成像和静止状态功能性MRI.
白球被细分为GPe和GPi.
临床评估包括扩展残疾状况尺度 (EDSS),定时25英尺步行 (T25FW),九洞测试 (9HPT) 和节奏听力序列加法测试 (PASAT).

主要成果:

在pwMS的GP中没有观察到显著的缩或改变的扩散性.
在GPe和GPi中,PwMS的T1/T2比率更高,与EDSS得分相关.
休息状态功能连接 (FC) 揭示了前额外皮层与前额外皮层的GPe FC降低和改变的GPi FC (降低了GP内,增加了thalamus).

结论:

在MS中,GP的结构性参与在其组件中是统一的.
增加T1/T2比率,可能表明铁积累,与更大的MS相关残疾有关.
改变的GPe和GPi功能连接与它们的网络角色保持一致,并且与功能状态较差相关,这表明基底腺网络内的通信受损.

关键词:

认知功能认知功能障碍残疾是指残疾人的残疾.球球 (Globus pallidus) 是一种的植物.磁共振成像技术磁共振成像技术运动器功能运动器功能多发性硬化症是多发性硬化症.

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