在妊娠高血压疾病后的心血管发病率和死亡率
Lauren H Theilen1, Michael W Varner1, M Sean Esplin1
1University of Utah Health, Department of Obstetrics and Gynecology, Salt Lake City, UT, United States; Intermountain Healthcare, Women & Newborn Clinical Program, Salt Lake City, UT, United States.
Pregnancy hypertension
|April 5, 2024
概括
妊娠高血压障碍 (HDP) 显著增加了女性冠状动脉疾病 (CAD) 和其他心血管疾病的长期风险. 这项研究发现,HDP在血管造影上使CAD的发病率增加了一倍,这凸显了产科史在心血管风险评估中的重要性.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 公共卫生 公共卫生
背景情况:
- 妊娠高血压障碍 (HDP) 是妊娠期间的一个重大并发症.
- 对于患有HDP的女性来说,长期心血管健康影响需要进一步调查.
- 了解HDP与晚期心血管疾病 (CVD) 之间的关联对于预防策略至关重要.
研究的目的:
- 调查妊娠高血压疾病 (HDP) 与母亲冠状动脉疾病 (CAD) 和其他心血管疾病的发病率之间的联系.
- 为了评估心血管疾病的风险10-20年分娩后的妇女与HDP的历史.
- 评估产科病史在指导女性心血管风险评估中的有用性.
主要方法:
- 对1998-2008年间分娩的妇女进行了回顾性队列研究,不包括那些具有先前存在心血管风险因素的妇女.
- 暴露被定义为通过ICD编码识别的任何HDP.
- 主要结局:包括CAD,外周血管疾病和心血管事件;嵌套队列通过心脏导管评估血管CAD.
主要成果:
- 这项研究包括33,959名女性,其中2,385名女性患有HDP.
- HDP与复合心血管结局相关 (调整HR为1.50).
- 与没有HDP的女性相比,患有HDP的女性患血管学CAD的发病率翻了一番 (22.2%与9.8%,调整后OR2.08).
结论:
- 孕期有高血压疾病史的妇女患冠状动脉疾病的风险显著增加.
- 这些发现表明,在评估女性心血管风险时,应该考虑产科史,特别是HDP,这可能为心脏导管决定提供信息.
- 在患有HDP的女性中,早期识别和管理心血管风险因素是有必要的.
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