宫癌中的围神经侵入:一个多中心的回顾性研究
Xiaolin Chen1, Hui Duan1, Hongwei Zhao2
1Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
概括
宫癌中围神经侵袭 (PNI) 诊断缺乏准确性. PNI是生存的独立风险因素,可以指导术后辅助治疗决策.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 妇科瘤学 妇科瘤学
背景情况:
- 周围神经侵入 (PNI) 是各种癌症的预后因素.
- 在宫癌中准确诊断PNI对于治疗计划至关重要.
研究的目的:
- 为了评估PNI在宫癌的诊断准确性.
- 分析PNI对预后和辅助治疗决策的影响.
主要方法:
- 在2004年至2016年期间,对1208例宫癌病例进行了回顾性病理审查.
- 对PNI诊断准确度,风险因素和生存结果的分析.
主要成果:
- 在PNI诊断中,虚假阴性 (33.33%) 和虚假阳性 (5.35%) 的比率很高.
- 腺癌,深层层层侵袭,淋巴血管空间侵袭 (LVSI) 和边缘参与是独立的PNI风险因素.
- 独立于治疗,PNI显著恶化了5年总生存率 (OS) 和无病生存率 (DFS).
结论:
- 宫癌的PNI诊断并不完全准确.
- PNI是子宫癌存活率的独立预后因素.
- PNI可能成为指导术后辅助治疗的高风险因素.
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