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Updated: Apr 25, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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革命性的发育神经毒性测试 - 从动物模型到先进的体外系统的旅程

Lena Smirnova1, Helena T Hogberg2, Marcel Leist3,4

  • 1Johns Hopkins University, Bloomberg School of Public Health and Whiting School of Engineering, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

ALTEX
|April 5, 2024
PubMed
概括

发育性神经毒性 (DNT) 测试的重大进展已经导致了一系列全面的体外测试方法 (DNT IVB). 这种无动物的方法提高了对化学物质对大脑发育的影响的理解.

关键词:
3Rss是什么意思没有动物的试验.非动物方法非动物方法.监管测试 监管测试 监管测试 监管测试 监管测试 监管测试科学 历史 科学 历史系统毒性 系统毒性

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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