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相关概念视频

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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相关实验视频

Updated: Jun 29, 2025

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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MLL4 结合了 TET3 的结合.

Dustin C Becht1, Sk Abdul Mohid2, Ji-Eun Lee3

  • 1Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Structure (London, England : 1993)
|April 5, 2024
PubMed
概括
此摘要是机器生成的。

混合血统白血病4 (MLL4) 通过其PHD6手指与十一转位3 (TET3) 相互作用. 这种相互作用发生在活性增强剂上,表明MLL4和TET3在基因调节中的功能联系.

关键词:
MLL4LL4 在线阅读在PHD手指指在TET3的基础上.互动互动互动互动互动.结构 结构 结构 结构

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科学领域:

  • 表观遗传学和转录的调节.
  • 在基因表达中的蛋白质-蛋白质相互作用.
  • 生物化学和结构生物学.

背景情况:

  • 混合血统白血病4 (MLL4),也称为KMT2D,对于增强器激活和细胞类型特定转录至关重要.
  • MLL4有一个催化域和七个植物本地域 (PHD) 指,后者的特征是有限的.
  • 十-十一转位3 (TET3) 是一种参与DNA脱甲基化的二氧化酶,将甲基化氨酸转化为氧化形式.

研究的目的:

  • 调查MLL4和TET3.3之间的相互作用.
  • 阐明MLL4-TET3结合的结构基础.
  • 探索这种相互作用在基因调节中的功能影响.

主要方法:

  • 解决方案核磁共振 (NMR) 对TET3-MLL4 PHD6复合体的结构确定.
  • 生物化学结合测试以表征相互作用.
  • 在小鼠胚胎干细胞中对MLL4和TET3进行基因组定位分析.

主要成果:

  • MLL4 (MLL4 PHD6) 的第六个PHD指直接与TET3.3上的疏水动机结合.
  • 结构分析显示,TET3占据了MLL4 PHD6上的一处疏水部位,类似于基因素H4.
  • 这种相互作用在MLL3的第七个PHD指 (MLL3 PHD7) 中得到保护.
  • 内源性MLL4和异位表达的TET3在它们在活性增强剂上的基因组定位上显著重叠.

结论:

  • MLL4 PHD6通过保留的疏水性结合点与TET3相互作用.
  • 重叠的基因组分布表明,在活性增强剂中,MLL4和TET3之间存在功能关系.
  • 这种相互作用可能在协调表观遗传修饰和DNA脱甲基化中发挥作用,用于转录控制.