使用微生理系统来建模转移性癌症
Caitlin E Jackson1,2, Nicola H Green1,2, William R English3
1Materials Science and Engineering, The Kroto Research Institute, University of Sheffield, Sheffield S3 7HQ, United Kingdom.
Biofabrication
|April 5, 2024
概括
微生理系统 (MPS) 为研究癌症转移提供先进的临床前模型. 这些可 perfusable 系统克服了传统模型的局限性,改善了新的癌症治疗方法的开发.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 翻译医学是一种翻译医学.
背景情况:
- 癌症转移是癌症相关死亡的主要原因,需要改进临床前模型.
- 传统的体外模型由于缺少可 perfusable 网络和有限的细胞异质性而缺乏生理相关性.
- 瘤微环境和免疫系统的关键组件在传统模型中经常缺失.
研究的目的:
- 审查微生理系统 (MPS) 的应用,以调查癌细胞转移.
- 突出MPS的进步,研究转移级联的单个和多个步骤.
- 讨论影响癌症研究MPS表现的因素和未来方向.
主要方法:
- 关于用于癌症转移研究的微生理系统的当前文献的综述.
- 分析MPS设计及其模仿转移级联的能力.
- 在癌症模型中探索影响MPS性能的因素.
主要成果:
- 微生理系统 (MPS) 正在成为克服静态体外癌症模型局限性的强大工具.
- 这些透气系统可以研究营养物质/废物交换和细胞相互作用,这些相互作用对转移至关重要.
- 最近的MPS进步允许同时调查转移级联的多个方面.
结论:
- 微生理系统 (MPS) 代表了临床前癌症转移研究的重大进展.
- 进一步开发和应用MPS对于改善瘤治疗的翻译至关重要.
- 应对挑战并探索未来的方向将增强MPS在癌症建模中的实用性.
相关概念视频
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...