精液等离子体,精子和子宫内膜之间的相互作用在马匹的物种间和物种内繁殖中
Giorgia Podico1, João H Bittar2, Shavahn C Loux3
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Reproduction (Cambridge, England)
|April 5, 2024
概括
与马匹的精液相比,与驴子精液进行的非物种繁殖并没有增加马匹精液的繁殖后炎症. 驴子精液血显示出抗炎性质,可能是由于前列腺素度较高.
科学领域:
- 生殖免疫学 生殖免疫学
- 马类繁殖的繁殖方式
- 比較免疫學 比較免疫學
背景情况:
- 在马匹中进行的非物种繁殖有时比物种内繁殖更成功.
- 驴子精液和精液等离子体对大马子宫内膜的免疫调节作用尚不清楚.
- 事证据表明,与驴一起繁殖的马匹的生育能力得到改善,炎症减少.
研究的目的:
- 为了比较暴露在驴子和马精液和精液等离子体中的马的繁殖后炎症反应.
- 评估驴子和马的精子和精液等离子体的蛋白质和代谢特征.
- 评估对子宫,液体积累,中性粒细胞透和细胞因子概况的影响.
主要方法:
- 在精液/精液等离子体输注前和后测量了大母子宫炎症标志物 (,液体,中性粒细胞,细胞因子).
- 分析了孕激素和炎症性细胞因子 (IL1A,IL1B,IL4,IL6,CXCL8,IL10) 的度.
- 使用LC-MS/MS进行了精液和精液等离子体的蛋白质和代谢分析.
主要成果:
- 驴子精液输液倾向于在输液后6小时导致较低的炎症反应 (P = 0.074).
- 在子宫细胞学中,驴精液血显著减少了中性粒细胞的透 (P < 0.05),表明具有抗炎性质.
- 马的精液增加了IL6和降低了IL1B度,而驴的精液/血显示了PGE1,PGE3和乳酸的度更高.
结论:
- 使用驴精液的繁殖母马引发了与马精液相似的繁殖后子宫内膜炎.
- 驴子精液血具有抗炎性质,与其他组合相比,导致炎症反应减少.
- 驴子精液/血中丰富的前列腺素可能有助于在物种间繁殖中产生免疫调节作用.
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