用dienogest长期治疗子宫内膜异位症:疗效,副作用和耐受性
Francesco La Torre1, Silvia Vannuccini1, Federico Toscano1
1Division of Obstetrics and Gynecology, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, AOU Careggi, Florence, Italy.
概括
迪恩诺杰斯特 (DNG) 有效地长期管理与子宫内膜异位症相关的疼痛,大多数患者表现出持续的坚持和疼痛减轻. 早期治疗的结果预测了长期遵守dienogest治疗的结果.
科学领域:
- 妇科 妇科医生 妇科
- 药理学 药理学是指药理学的学科.
- 生殖医学 生殖医学
背景情况:
- 迪恩诺杰斯特 (DNG) 被认为可以改善子宫内膜异位症相关的疼痛 (EAP) 和生活质量.
- 长期的患者坚持治疗对于有效的子宫内膜异位症管理至关重要.
研究的目的:
- 评估dienogest (DNG) 作为一个长期的子宫内膜异位症治疗.
- 为了评估不同子宫内膜异位症表型的患者遵守,副作用和疗效.
主要方法:
- 一项包括114名长期接受DNG治疗的子宫内膜异位症患者的队列研究.
- 12,24和36个月的后续评估包括疼痛 (VAS) 和副作用问卷.
主要成果:
- 在12个月后,81%的人继续使用DNG,EAP显著减少;停药主要是由于斑点和情绪变化. 在所有表型中,EAP有所改善,特别是深透性子宫内膜异位症.
- 在36个月后,73%的人继续使用DNG,显示了持续的EAP减少和增加的异常流失率 (93%).
- 在患有胃肠道问题的小组中,通过阴道给予DNG产生了类似的疗效和耐受性.
结论:
- 迪恩诺杰斯特 (DNG) 在所有表型的子宫内膜异位症的长期治疗中表现出有效性,并具有可管理的副作用.
- 治疗坚持通常在第一年内建立,使最初一年的过程是长期遵守的预测.
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