Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Piaget's Stage 1 of Cognitive Development01:14

Piaget's Stage 1 of Cognitive Development

621
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
621
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

389
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
389
Neurotransmitters01:31

Neurotransmitters

898
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
898
Rab Cascades01:25

Rab Cascades

2.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
2.6K
The Nativist Approach01:21

The Nativist Approach

48
The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to...
48
Piaget's Theory of Cognitive Development from Childhood into Adulthood01:25

Piaget's Theory of Cognitive Development from Childhood into Adulthood

109
Jean Piaget's theory of cognitive development emphasizes the role of thinking in a child's learning process, suggesting that children are naturally curious about their environment. His approach to development is discontinuous, proposing that cognitive abilities progress through distinct stages, each with unique characteristics. Central to Piaget's theory is schemata—mental structures that allow individuals to understand and interpret the world.
Schemata: Building Blocks of...
109

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A critical role for the anterior insula in impaired adult social interaction after early life maltreatment.

bioRxiv : the preprint server for biology·2026
Same author

The role of GABA<sub>A</sub> receptors in hippocampus-dependent cognitive functions.

Neuroscience and biobehavioral reviews·2026
Same author

Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally.

bioRxiv : the preprint server for biology·2025
Same author

Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation.

JVS-vascular science·2025
Same author

Hemodynamics in carotid artery stenosis.

International angiology : a journal of the International Union of Angiology·2025
Same author

Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes.

Brain : a journal of neurology·2025

相关实验视频

Updated: Jun 29, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K

作为早期发育的因果关系的GABA系统.

Irina Topchiy1, Julie Mohbat2, Oluwarotimi O Folorunso1

  • 1Division of Basic Neuroscience, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.

Neuroscience and biobehavioral reviews
|April 5, 2024
PubMed
概括

胺黄油酸 (GABA) 对大脑发育和功能至关重要. 在GABA系统发育中出现的障碍可能会导致广泛的问题,而其长期成熟使其容易受到侮辱.

关键词:
早期发展 早期发展早期生活中的压力.胎儿酒精综合征 胎儿酒精综合征对于GABA来说,这是一个很好的选择.在GABAA受体中,GABAA受体具有孕产妇的免疫激活

更多相关视频

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.4K
Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
07:32

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices

Published on: October 12, 2017

9.4K

相关实验视频

Last Updated: Jun 29, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K
Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.4K
Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
07:32

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices

Published on: October 12, 2017

9.4K

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 神经化学 神经化学

背景情况:

  • 胺黄油酸 (GABA) 是成人大脑中主要的抑制性神经递质.
  • 该GABA系统指导早期的大脑发育,前面的谷氨酸质系统.
  • GABA系统的成熟延伸到出生后早期.

研究的目的:

  • 审查GABA系统在大脑发育中的双重作用.
  • 组织围绕GABA作为发育障碍的原因或影响的证据.
  • 为了确定了解GABA的发育机制的知识差距.

主要方法:

  • 对关于GABA系统发展的现有证据的文献综述.
  • 将发现组织成两个发展场景.
  • 分析GABA作为发育侮辱的原因和影响的作用.

主要成果:

  • GABA系统的早期发育影响其他大脑系统.
  • 长期成熟的GABA系统使其容易受到发育性侮辱.
  • 证据支持GABA在两个发育场景中的关键作用.

结论:

  • 对于正常的大脑发育来说,GABA系统是必不可少的,它既是基础元素又是脆弱系统.
  • 需要进一步的研究来阐明GABA系统动态和发育结果之间的精确机制联系.
  • 了解这些机制对于解决神经发育障碍至关重要.