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异常的动态功能网络连接在渐进的超核性麻中

Junyu Qu¹, Min Tian², Rui Zhu¹

¹Department of Radiology, Qilu Hospital of Shandong University; Qilu Medical Imaging Institute of Shandong University, Ji'nan, China.

Neurobiology of disease

|April 5, 2024

概括

渐进性超核性麻 (PSP) 患者表现出改变的动态功能网络连接 (dFNC),特别是涉及小脑和长髓. 这些变化与症状严重程度相关,这表明dFNC变化是PSP神经机制的关键.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
系统生物学系统生物学

背景情况:

渐进性超核性 (PSP) 的临床症状可能源于异常的动态功能网络连接 (dFNC).
以前的研究主要集中在PSP中的静态功能连接上,忽视了动态网络变化.
本研究研究了PSP中的动态功能连接性变化及其临床相关性.

研究的目的:

评估PSP患者动态功能网络连接 (dFNC) 的修改.
为了将观察到的dFNC变化与PSP中的临床变量相关联.

主要方法:

利用组独立组件分析 (ICA) 来识别静止状态网络 (RSN).
采用滑窗相关性方法来生成动态功能网络连接 (dFNC) 矩阵.
应用了K-means集群和状态分析,以比较53名PSP患者和65名对照者的dFNC和时间指标,然后进行相关性分析.

主要成果:

在PSP患者中,延长性脑髓 (MO) 和视觉/小脑网络 (VN/CBN) 之间,以及默认模式/皮下网络 (DMN/SCN) 与CBN之间的连接性发生了变化.
PSP患者在扩散网络状态中花费的时间减少了,特别是涉及MO和SCN.
在分布式连接状态下减少的分数和停留时间与PSP症状持续时间和严重程度 (气囊,眼运动) 有负相关性.

结论:

在PSP中改变的功能连接集中在小脑网络 (CBN) 和长髓 (MO) 中.
在PSP患者中观察到dFNC的独特时间动态,与腹筋和眼运动症状有关.
动态功能网络连接特性代表了PSP的基础的神经系统机制.

关键词:

小脑网络的网络.默认模式的网络模式是默认模式.动态功能网络连接能力动态功能网络连接长髓 (Medulla oblongata) 是一个长髓.渐进性的超核性.皮层下皮层网络网络

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