相关实验视频

Updated: Jun 29, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

产前颗粒物暴露与生命早期的神经行为发育有关

Charlotte Cosemans¹, Narjes Madhloum², Hanne Sleurs¹

¹Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, 3590, Diepenbeek, Belgium.

Environmental research

|April 5, 2024

概括

产前暴露于细颗粒物 (PM2.5) 与婴儿和幼儿的神经行为变化有关. 怀孕期间的特定暴露期可能会影响新生儿的调节和以后的社会行为,突出了关键的发育窗口.

科学领域:

环境健康环境健康
神经发育儿科神经发育儿科
流行病学流行病学

背景情况:

暴露于环境颗粒物 (PM) 的早期生活可能会对儿童的神经行为发展产生不利影响.
产前暴露于PM2.5对认知,情感和社会功能越来越关注.
这项研究调查了在不同发育阶段产前PM2.5暴露的影响.

研究的目的:

检查产前PM2.5暴露与新生儿和儿童神经行为发育之间的关联.
在怀孕期间识别PM2.5暴露影响的敏感时间窗口.
评估神经行为结果使用标准化的评估在幼儿时代.

主要方法:

使用ENVIRONAGE出生队列,沿纵跟随母婴对.
使用新生儿行为评估量表 (NBAS) 评估了88名新生儿 (1-2个月).
通过强项和困难问卷 (SDQ) 评估了393名儿童 (4-6岁).
通过高分辨率的时空方法确定产前PM2.5暴露.
采用多个线性和多项逻辑回归模型进行分析.

主要成果:

第一季度PM2.5的5μg/m3增加与新生儿的NBAS状态调节得分较低有关 (p=0.04).
第一个三个月的PM2.5暴露与4-6岁儿童同龄人问题增加的几率有关 (OR=3.89,p=0.01).
第二个三个月的PM2.5暴露与儿童的异常亲社会行为有关 (OR=0.49,p=0.04).
没有发现过度活跃或行为问题存在重大关联.

结论:

产前的PM2.5暴露会对新生儿和学龄前儿童的神经行为发展产生负面影响.
在怀孕早期到中期的敏感窗口中确定了对新生儿调节,同行互动和亲社会行为的影响.
这些发现强调了减少产前PM2.5暴露对儿童神经发育的重要性.

关键词:

空气污染大气污染新生儿行为评估尺度.神经行为发展神经行为发展优势和困难问卷问卷

更多相关视频

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

相关概念视频

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...