青春期早期的Per-和多基基物质和骨矿物质含量:通过饮食和体力活动进行修改
Jessie P Buckley1, Junyi Zhou2, Katherine M Marquess3
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Environmental research
|April 5, 2024
概括
暴露于和多醇基物质 (PFAS) 可能会损害青少年的骨健康. 然而,健康饮食丰富的和定期体育活动可以防止这些负面影响.
科学领域:
- 环境健康 环境健康
- 儿童骨健康 儿童骨健康
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是环境污染物,与青少年骨矿物质积累的潜在负面影响有关.
- 关于可能减轻在关键发育时期暴露于PFAS对骨健康的不良影响的因素的研究有限.
研究的目的:
- 调查饮食因素和体力活动是否会改变青少年血清PFAS度和骨矿物质含量 (BMC) 之间的关联.
- 评估单个PFAS和PFAS混合物对青少年BMC的影响.
主要方法:
- 在俄俄州辛辛那提的197名青少年 (12岁) 的前性队列研究.
- 测量了血清PFAS水平,骨矿物质含量 (BMC) 通过DXA,饮食摄入量和HEI得分,以及身体活动 (PAQ-C,MVPA加速计).
- 使用线性回归和g计算来估计关联,通过相互作用术语评估效果测量修改.
主要成果:
- 特定PFAS (PFOS,PFOA,PFNA) 和PFAS混合物的较高度与青少年的BMCz分数较低有关.
- 这些负面关联在摄入量较低,体力活动中度至强度较低 (MVPA) 的青少年中通常更强.
- 例如,所有PFAS的IQR增加与远半径BMCz-score在摄入量低于中位数的人群中的较大下降有关,而与摄入量高于中位数的人群相比.
结论:
- 青少年的摄入量较高,体力活动较强,可以保护他们免受PFAS对骨矿物质含量的有害影响.
- 促进健康的生活方式选择,包括饮食和运动,可能是减轻青少年骨健康的PFAS相关风险的策略.
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