合成和描述mupirocin-LDH/PVA纳米纤维复合物作为双载体药物释放系统
Zahra Majidi Qadikolaei1, Sayed Mahmood Rabiee2, Adeleh Gholipour-Kanani3
1Department of Materials Engineering, Babol University of Technology, P.O. Box: 47148711167, Babol, Iran.
International journal of biological macromolecules
|April 5, 2024
概括
这项研究开发了一种双载体药物递送系统,在聚乙烯醇 (PVA) 纳米纤维结构中使用带有mupirocin的分层双氧化物 (LDH) 来增强伤口愈合. 该系统表现出有效的长期抗菌特性和生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 纳米纤维结构被用来控制抗菌剂的释放.
- 层状双氧化物 (LDH) 和mupirocin为药物输送提供了独特的特性.
- 开发双载体系统可以增强伤口愈合的长期治疗效果.
研究的目的:
- 将纳米纤维结构与含有mupirocin的ldh结合起来,以实现双载体抗生素释放系统.
- 为改善伤口愈合提供持续的抗菌特性.
- 研究新型纳米复合材料的物理化学和生物特性.
主要方法:
- 通过共同沉来合成未加载和mupirocin加载的ldh.
- 基于聚乙烯醇 (PVA) 的纳米纤维复合材料的制造,使用电.
- 使用SEM,FTIR和抗拉强度测试进行物理化学表征.
- 通过抗菌试验和MTT测定对生物性质的评估.
主要成果:
- 对于Mupirocin(2.3重%) -LDH(15重%) /PVA复合物,SEM证实了统一的,没有珠的纳米纤维形态,平均纤维直径为270±58nm.
- 药物释放研究显示,在前6小时内,mupirocin的最大释放量约为54%.
- 抗菌试验表明,对格拉姆阳性和格拉姆阴性细菌都有显著的活性.
- MTT测定证实了Mupirocin载入的纳米复合材料的生物相容性.
结论:
- 开发的含Mupirocin的LDH/PVA纳米纤维复合材料作为一种有效的双载体系统.
- 该系统提供受控的抗生素释放和持续的抗菌活性,用于伤口愈合应用.
- 纳米复合材料在先进的伤口护理管理方面表现出有前途的潜力.
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