子宫内热过热对上腺发育的编程效应
Anne R Guadagnin1, Francisco Peñagaricano1, Geoffrey E Dahl2
1Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706.
Journal of dairy science
|April 5, 2024
概括
怀孕期间母亲的热应激会扩大后代的上腺,改变基因表达,可能会影响未来的压力和免疫反应. 这些发现凸显了子宫内热暴露对牛发育的长期影响.
科学领域:
- 生殖生理学 生殖生理学
- 发展生物学 发展生物学
- 动物科学动物科学
背景情况:
- 孕期晚期母亲的热应激会对胎儿发育产生负面影响.
- 宫内热量过高可能会影响胎儿下丘脑-垂体-上腺轴的发育和功能.
- 在怀孕晚期暴露于热应激的霍尔斯坦牛被研究以评估后代的上腺发育.
研究的目的:
- 调查慢性孕产妇热应激对荷尔斯泰因母牛后代上腺体组织形态学和转录组的影响.
- 为了确定子宫内热暴露是否会改变新生儿和断奶小母牛的上腺结构和基因表达.
- 为了确定胎儿热应激对上腺功能潜在的长期后果.
主要方法:
- 在怀孕晚期的霍尔斯坦牛被分为热应激 (HS) 和主动冷却 (CL) 组.
- 后代的上腺在出生时和断奶1周后被采集,用于组织形态学和转录基因分析.
- 监测了呼吸速率,皮肤温度和循环中的皮质醇水平.
- 通过转录基因剖析识别识别了不同的基因表达途径.
主要成果:
- 热应激水的呼吸率和皮肤温度都更高.
- 暴露于子宫内热应激 (HS) 的母牛具有更重的上腺腺,并增加了球膜,状腺和网状腺的厚度.
- HS公牛的上腺细胞形态发生了变化 (ZG细胞少,ZF细胞多/大,ZR细胞大) 以及与免疫功能,炎症和信号传递相关的途径中的差异性基因表达.
结论:
- 孕期晚期母亲的热应激会导致后代上腺体大小,细胞结构和基因表达的显著变化.
- 这些变化表明,在以后的生活中,潜在的倾向性改变了压力,免疫和代谢反应.
- 这项研究表明,子宫内热过热对牛上腺发育和分子编程有持久的影响.
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