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喉瘤的发病率,特征,评估和管理:基于现有证据的系统分析

Yong-Hong Wang¹, Jia Yang¹, Hao Zhong¹

¹Department of Cardiovascular Surgery, Qinghai University Affiliated Hospital, Xi'ning, China; Medical College of Qinghai University, Qinghai University, Xi'ning, China.

Journal of vascular surgery

|April 5, 2024

概括

状体瘤 (CBT) 在中年女性中最常见. 早期手术切除是可行的,并发症率低,但由于中风风险增加,不建议进行常规的手术前栓塞 (PE).

科学领域:

内分泌学在内分泌学.
手术瘤学手术瘤学
遗传学遗传学是一个

背景情况:

状体瘤 (CBT) 是罕见的,但由于恶性转变的潜力和高的外科复杂性,具有重大风险.
关于CBT特征,管理和并发症的数据有限,阻碍了全面的分析.

研究的目的:

系统地分析有关CBT的现有数据,以了解疾病特征,管理策略和手术并发症.
为了比较经过手术前栓塞 (PE) 和非PE患者之间的结果,并评估Shamblin等级和SDH突变的影响.

主要方法:

在PubMed,Embase,Cochrane图书馆和Web of Science的系统文献搜索到2022年12月1日.
对155项涉及9291名患者和9862名CBT的研究进行了聚合分析.
对PE与非PE,Shamblin等级和SDH突变状态的统计比较.

主要成果:

接受CBT治疗的患者中位数年龄为45.72岁,女性为65%. 在36%的患者中发现了SDH基因突变.
头骨神经损伤 (CNI) 的发生率为27% (14%永久). 术后死亡率和中风率为1%. 恶性/转移发生在6%的CBT中.
PE减少了血液流失和手术时间,但增加了中风发生率. 较高的Shamblin成绩与更多的手术并发症相关.

结论:

主要影响中年女性的CBT;早期手术切除是可行的,严重并发症率较低.
由于中风风险增加,不建议进行常规PE,尽管在血液流失和手术时间方面有好处.
高尚布林级瘤与手术并发症的增加有关;SDH突变阳性患者表现出更多的家族病史和症状.

关键词:

冠状动脉体瘤是什么意思它们的特征和特征.评价评价评价管理管理管理管理流行程度流行程度

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