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儿童中药物诱导的红斑狼:基于病例的审查

Ummusen Kaya Akca¹, Seher Sener¹, Ezgi Deniz Batu¹

¹Department of Pediatrics, Division of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.

|April 5, 2024

概括

药物诱导性红斑狼 (DILE) 在儿童中不常见,但这项研究强调了四个病例,并审查了文献,发现埃索苏西米德和米诺环素是常见的罪祸首. 及时戒药导致症状缓解,强调了药物历史的重要性.

科学领域:

儿科风湿病学儿科风湿病学
临床药理学临床药理学

背景情况:

药物诱导性红斑狼 (DILE) 是一种疾病,在药物暴露后模仿全身性红斑狼 (SLE).
与成年人相比,儿童群体中DILE的发生频率较低.

研究的目的:

为了介绍四个儿童病例的DILE.
系统地审查关于童年的出版文献 DILE.
确定与儿童DILE相关的常见药物,临床特征和结果.

主要方法:

一系列关于四个患有DILE的儿童的案例.
儿童DILE病例的系统文献综述.
分析临床表现,相关药物,血清学发现和治疗结果.

主要成果:

四名儿童患有与托皮拉,多西环素,乙素和乙素胺相关的DILE.
文献审查发现了另外61例儿科DILE病例,其中埃索苏西米德和米诺环素是最常见的.
常见的症状包括发烧,关节痛,皮疹和关节炎; ANA在93.5%的患者中呈阳性,而抗希斯抗体在72.2%的患者中.
停止使用侵权药物导致所有病例的症状完全消失,总体改善率为92.0%.

结论:

在患有SLE类症状的儿童中,DILE可能比以前认为的更为普遍.
彻底的药物史对于诊断儿科患者的DILE至关重要.
药物戒断后症状的消失强烈支持DILE诊断.

关键词:

药物诱导的狼是药物引起的狼.孩子们的孩子们的孩子们的孩子们.药物诱导的全身性红血性狼.与毒品相关的狼

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