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大脑图谱:一个多面的脑图,包括分片,连接和组织学

Yuheng Lu¹, Yue Cui², Long Cao³

¹Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China.

Science bulletin

|April 5, 2024

概括

研究人员创建了大脑图谱 (MacBNA),这是一个基于扩散MRI连接的全脑图. 这本地图详细介绍了304个区域及其联系,有助于比较神经科学研究.

科学领域:

神经科学是一个神经科学.
比较解剖学的比较解剖学
医疗成像医学成像

背景情况:

rhesus macaques 是重要的研究模型,因为它们具有类似人类的特征.
一个基于连接的大脑地图是必不可少的,但以前没有.
了解大脑连接对于功能和进化至关重要.

研究的目的:

根据解剖学连接,开发了第一个基于的全脑图谱.
将大脑中的结构和功能连接映射出来.
为比较和翻译神经科学提供资源.

主要方法:

利用高角度和空间分辨率的体外扩散MRI数据.
开发了"大脑图谱图谱" (MacBNA),其中包括248个皮层和56个皮层下区域.
使用神经元追踪和组织学验证的分片和曲谱.

主要成果:

澳门大脑图谱 (MacBNA) 成功创建,详细介绍了区域连接.
绘制了和人类大脑之间的结构连接差异.
编制了一个包括MRI,通道图和组织学在内的全面数据集.

结论:

在研究中,MacBNA 作为多模式数据集成的参考.
这本地图书有助于对大脑演变和功能进行比较研究.
这个资源支持非人类灵长类动物的协作研究和翻译神经科学.

关键词:

大脑图书馆大脑图书馆基于连接性的分片划分.跨物种对比跨物种对比细胞架构细胞架构扩散式核磁共振成像 (MRI)澳门子 (Macaca mulatta) 是一个有趣的动物.

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