低功能网络完整性在认知不受损和MCI受试者抑郁症状:多中心fMRI研究的结果
Gabor Csukly1,2, László Tombor3, Zoltan Hidasi3
1Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary. csugab@yahoo.com.
Translational psychiatry
|April 5, 2024
概括
老年人的抑郁症可能源于大脑网络功能障碍,而不仅仅是病变. 增加的网络路径长度和前临界网络中受损的连接性与抑郁症状和严重程度有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 老年人的抑郁症状越来越多地与大脑网络功能障碍有关,而不是焦点病变病理.
- 了解功能连接性改变对于阐明老年人抑郁症的神经生物学基础至关重要.
研究的目的:
- 通过使用图形理论来研究患有抑郁症症状的老年人中的全脑功能连接和特定网络变化.
- 检查网络指标,抑郁症状严重程度和认知状态 (轻度认知障碍) 之间的关系.
主要方法:
- 采用最小跨度树 (MST) 图形理论方法,从183名老年人中的3次特斯拉MRI扫描中分析全脑功能连接.
- 使用贝克抑郁量库 (BDI) 或老年抑郁量表 (GDS) 评估抑郁症状.
- 将参与者分为抑郁症/非抑郁症组,并按认知状态分类 (记忆障碍MCI,非记忆障碍MCI,健康对照).
主要成果:
- 患有抑郁症状的老年人表现出平均偏心率和网络直径的增加,这表明功能网络配置更类似于路径.
- 这些网络变化 (离心率,直径) 与抑郁症状严重程度正相关.
- 在抑郁症患者中,在前皮质 (ACC) 和前皮质网络 (FLN) 中的右桃体之间观察到功能性低连接性,与症状严重程度相关.
结论:
- 在老年人中,增加网络路径长度和功能整合障碍可能是抑郁症症状的基础.
- 虽然没有发现与抑郁本身相关的结构差异,但MCI与海马体积和皮层厚度的减少有关.
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