最近,摩尔多瓦的多药耐药乌拉尔血统的结核菌在摩尔多瓦迅速扩散
Melanie H Chitwood1, Caroline Colijn2, Chongguang Yang3
1Department of Epidemiology of Microbial Disease, Yale School of Public Health, 60 College Street, New Haven, CT, USA. melanie.chitwood@yale.edu.
Nature communications
|April 5, 2024
概括
多药耐药结核病 (MDR-TB) 在摩尔多瓦的乌拉尔菌株表现出比其他菌株更高的适应性,表明有效的传播. 这一发现凸显了该地区MDR-TB传播的重大风险.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 多耐药结核病 (MDR-TB) 的传播受到Mycobacterium tuberculosis (Mtb) 菌株的适应性的影响.
- 北京亚系 (系 2.2.1) 与MDR Mtb.的抗性发展和适应性增加有关.
- 了解血统特定的适应性对于预测MDR-TB流行病轨迹至关重要.
研究的目的:
- 在摩尔多瓦估计乌拉尔 (系谱4.2) 和北京MDR Mtb菌株的适应性.
- 确定有助于该地区MDR Mtb菌株适应性的遗传因素.
主要方法:
- 分析两年来摩尔多瓦所有培养阳性病例的Mtb基因组序列.
- 不同的Mtb血统 (乌拉尔,北京) 和易感概况 (MDR与易感) 之间的比较适应性估计.
- 鉴定特定于高适应性MDR菌株的突变.
主要成果:
- 与其他敏感菌株和MDR Mtb菌株相比,MDR乌拉尔菌株的健康状况显著提高.
- 特别是在MDR乌拉尔菌株中发现了几种新型突变.
- 有证据表明,MDR乌拉尔Mtb在摩尔多瓦境内有效传播.
结论:
- 摩尔多瓦的MDR乌拉尔Mtb菌株的高适应性表明有效的传播和区域传播的重大风险.
- 在MDR乌拉尔菌株中的遗传适应可能有助于它们的成功传播.
- 需要进一步的监测和控制策略来应对适合MDR-TB菌株带来的威胁.
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