人类表皮生长因子受体-2表达和随后的动态变化在患有卵巢癌的患者
Yoo-Na Kim1, Yun Soo Chung1, Eunhyang Park2
1Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Scientific reports
|April 5, 2024
概括
在卵巢癌 (OC) 中存在HER2表达,随着时间的推移观察到动态变化. 向HER2的药物可能有利于BRCA野生型OC患者,特别是在后期的治疗线上.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 人类表皮生长因子受体-2 (HER2) 向正在扩大到乳腺癌之外.
- 在卵巢癌 (OC) 中HER2表达数据仍然有限.
- 了解HER2状态对于OC的新型治疗策略至关重要.
研究的目的:
- 调查卵巢癌中HER2表达的流行率和动态变化.
- 为了将HER2状态与临床病理学和基因组特征相关联.
- 评估HER2向治疗在OC中的潜力.
主要方法:
- 200名接受HER2测试的卵巢癌患者的回顾性审查.
- 对HER2表达的免疫组织化学 (IHC) 分析.
- 对组织学,BRCA状态和基因组突变 (TP53,ARID1A,KRAS,PIK3CA) 的评估.
- 评估19名连续活检患者的动态HER2变化.
主要成果:
- 28%和6%的OC病例显示HER2表达分数分别为2+和3+.
- 在粘膜 (23%) 和子宫内膜 (11%) 亚型中,HER2 3+最常见.
- HER2过度表达与BRCA野生型,MMR熟练和PD-L1-低的个人资料有关.
- 在HER2得分较高的情况下,ARID1A,KRAS和PIK3CA突变更常见.
- 在19名患者中,11名患者在连续活检中表现出HER2表达的增加.
结论:
- 过度表达HER2的OC表现出不同的组织学和基因组资料.
- 在卵巢癌中,HER2表达可以动态变化.
- 针对HER2的药物代表了BRCA野生型OC患者的潜在治疗途径,特别是在晚期治疗阶段.
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