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Updated: Jun 29, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Published on: June 21, 2018

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跨祖先的互乐金-6受体变体和表型之间的异质关联以及对治疗的影响

Xuan Wang1, Molei Liu2, Isabelle-Emmanuella Nogues3

  • 1Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.

Scientific reports
|April 5, 2024
PubMed
概括

一种新方法有效地测试了现象广泛关联研究 (PheWAS) 中的子组差异. 这种方法揭示了跨祖先的IL6R变异-表型关联差异,包括2型糖尿病风险.

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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