胃癌手术后肝功能障碍的危险因素及其临床重要性
Shutaro Sumiyoshi1, Takeshi Kubota2, Takuma Ohashi1
1Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Scientific reports
|April 5, 2024
概括
机器人手术可能会增加胃癌 (GC) 患者术后肝功能障碍的风险. 然而,这种肝功能障碍并不影响患者的治疗结果或生存率.
科学领域:
- 胃肠病学和肝病学
- 手术瘤学手术瘤学
- 最少侵入性的手术
背景情况:
- 手术后的肝功能障碍,由异常的肝胆酶表明,是胃癌 (GC) 手术中的一个问题.
- 识别风险因素和临床影响对于进行GC手术的患者的管理至关重要.
研究的目的:
- 为了确定胃癌手术后术后肝功能障碍的危险因素.
- 评估术后肝功能障碍对患者结局的临床影响.
主要方法:
- 对124名经过腹腔镜或机器人手术的胃癌患者进行了回顾性分析.
- 2017年至2019年间在京都县医学大学收集的数据.
- 术后肝功能障碍是根据常用术语对不良事件标准 (CTCAE) 版本5.0≥3级定义的.
主要成果:
- 16.1%的GC患者出现了术后肝功能障碍.
- 单变量分析发现机器人手术是显著的风险因素 (P=0.005).
- 在肝功能障碍和术后并发症或住院期间之间没有发现相关性.
- 两组之间整体存活率或无复发存活率没有显著差异.
结论:
- 机器人手术被确定为胃癌患者术后肝功能障碍的危险因素.
- 手术后肝功能障碍似乎不会对患者的短期或长期结果产生负面影响.
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