多模态神经成像在老年大脑中记忆性无意识症的表型化
Elisenda Bueichekú1, Ibai Diez1,2, Geoffroy Gagliardi3
1Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Communications medicine
|April 5, 2024
概括
没有意识到老龄化中的记忆力下降与早期阿尔茨海默病 (AD) 病理学有关. 这项研究揭示了大脑默认模式网络中粉样蛋白和蛋白的积累与这种无意识相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 没有意识,缺乏对记忆力下降的自我意识,可以表现为阿尔茨海默氏病 (AD) 的前发性阶段.
- 这种情况可能会加剧疾病的严重程度和进展.
- 这项研究调查了老龄化期间记忆自我意识改变的个体的大脑特征.
研究的目的:
- 描述与老年人记忆力下降的不意识相关的大脑表型.
- 为了识别与记忆的自我意识改变相关的神经成像标记.
主要方法:
- 使用了体内多模式神经成像:粉样蛋白-PET,蛋白-PET (N=335),以及静止状态功能性MRI (N=713).
- 数据来源于无症状阿尔茨海默病的抗粉样蛋白治疗 (A4) /长度评估粉样蛋白风险和神经退行 (LEARN) 研究.
- 应用全脑克塞尔智能和兴趣区域分析来检查与无意识相关的,粉样蛋白和功能连接.
主要成果:
- 与意识或对照组相比,没有意识的个体在默认模式网络中线区域中显示出更高的粉样蛋白和蛋白负担.
- 无意识与功能性网络连接的改变有关,特别是中间前额头和后侧尾-尾区域的超连接性.
- 这些连接性变化与粉样蛋白和沉积共同定位.
结论:
- 没有意识是阿尔茨海默病 (AD) 病理学的早期行为生物标志物.
- 在无意识的情况下,自我参考处理受损与粉样蛋白和陶负担有关.
- 在中枢前额和尾脑区域内的功能网络连接中断与记忆力下降的不意识有关.
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