在治疗耐药抑郁症患者中,经过间脉冲电磁场后的大脑激活的变化
Sjoerd M van Belkum1,2, Esther M Opmeer3, Hanneke Geugies4
1Department of Psychiatry, Research School of Behavioral and Cognitive Neurosciences (BCN), Interdisciplinary Center Psychopathology of Emotion Regulation (ICPE), University Medical Center Groningen, University of Groningen, PO Box 30.001 (CC30), 9700 RB, Groningen, The Netherlands. s.m.van.belkum@umcg.nl.
概括
跨脉冲电磁场 (tPEMF) 降低了治疗耐药抑郁症患者的奖励电路激活. 这种神经刺激影响了大脑活动,但没有显示立即的抗抑郁作用或影响情绪处理.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 超脉冲电磁场 (tPEMF) 显示了初步的抗抑郁药物潜力.
- 导致tPEMF影响的确切大脑机制尚不清楚.
- 耐治疗抑郁症 (TRD) 是一个重大的临床挑战.
研究的目的:
- 研究TPEMF对TRD患者大脑激活的影响.
- 检查tPEMF对情绪和奖励处理电路的影响.
- 探索TPEMF的潜在神经生物学机制.
主要方法:
- 一个模拟控制,双盲,多中心试验,涉及50名TRD参与者.
- 五周的每日活跃或假的tPEMF治疗.
- 在社会情感和奖励任务中,治疗前后的功能性MRI扫描.
主要成果:
- 活跃的tPEMF导致奖励处理区域 (左下额头环,右舌头环,中环) 的激活减少,与假的相比.
- 没有观察到tPEMF对社会情感任务激活的显著影响.
- 两项任务的行为表现都不受tPEMF的影响.
结论:
- tPEMF刺激降低了与奖励相关的大脑回路的激活.
- 观察到的激活减少可能表明调节性大脑区域的正常化.
- 结果表明tPEMF影响相关的大脑电路,可能会影响无情,尽管没有立即的临床抗抑郁作用.
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