乳腺癌 (BC) 和严重的COVID-19 (C-19) 结果:一个匹配的分析
Marija Sullivan1, Xiudong Lei2, Sharon H Giordano2,3
1Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Breast cancer research and treatment
|April 5, 2024
概括
接受治疗的乳腺癌 (BC) 患者与没有癌症的患者面临类似的COVID-19 (C-19) 风险. 然而,最近的化疗增加了BC患者住院的风险.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 接受癌症治疗的癌症患者面临严重COVID-19 (C-19) 结果的风险增加.
- 了解乳腺癌及其治疗对C-19结果的具体影响对于患者管理至关重要.
研究的目的:
- 为了检查乳腺癌 (BC),最近的抗癌治疗 (全身疗法,手术,辐射) 和COVID-19 (C-19) 结果之间的关联.
- 为了比较最近接受治疗的BC患者与未接受治疗的BC患者以及没有癌症的患者的C-19结局.
主要方法:
- 追溯匹配队列研究,使用非识别的COVID-19电子健康记录数据集 (2007-2022).
- 患有C-19的患者被分为三个组:没有癌症,最近接受过治疗的BC和最近没有治疗的BC.
- 评估的结果包括30天死亡率,机械通风,ICU住院和住院,使用多变量后勤回归分析.
主要成果:
- 包括2200个匹配的三胞胎 (最近接受过BC治疗的患者,最近没有接受BC治疗的患者,没有癌症).
- 与没有癌症的患者相比,最近接受BC治疗的患者具有类似的整体不良C-19结果 (OR=1.02).
- 最近没有接受过治疗的BC患者表现更好 (OR=0.66). 在BC患者中,最近3个月内的化疗与更高的住院风险 (OR=2.30) 和复合结局风险 (OR=2.11) 相关.
结论:
- 与没有癌症的患者相比,乳腺癌患者通常面临类似的严重COVID-19风险.
- 乳腺癌患者最近的化疗治疗与住院和不良COVID-19结果的风险增加有关.
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