基于条件功率的β支出函数在组序列设计中的组序列设计中
Senmiao Ni1, Zihang Zhong1, Zhiwei Jiang2
1Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Biometrical journal. Biometrische Zeitschrift
|April 6, 2024
概括
本研究引入了一种新的CP-β支出函数,用于组序列设计,以更好地控制徒劳性监测期间的II型错误. 该方法确保了精确的错误率控制,并保持了整体I型错误率,提高了试验设计的灵活性.
科学领域:
- 统计 统计 统计 统计
- 临床试验设计 临床试验设计
背景情况:
- 条件功率 (CP) 对于在组序列试验中徒劳性监测至关重要.
- 现有的CP方法可能会损害II型错误率控制.
- 需要灵活的方法来管理无用性监测中的II型错误率.
研究的目的:
- 引入一个灵活的CP-beta支出函数用于徒劳性监测.
- 规范整个试验的II型错误率支出.
- 在CP框架内集成beta支出概念,以精确控制错误.
主要方法:
- 开发了一种新的CP-β支出函数.
- 整合了一个预先确定的标准化效果大小,用于徒劳性监控.
- 使用集成计算停止边界,类似于传统的β支出函数.
主要成果:
- CP-beta支出函数精确控制无用性监控期间的II型错误率.
- 在各种信息时间场景和CP门中表现出适应性.
- 模拟研究和现实世界的试验实例证实了精确的功率捕获和I型错误率控制.
结论:
- 拟议的CP-beta支出函数为组序列设计提供了竞争性和灵活的替代方案.
- 便于在各种临床试验环境中直接实施.
- 有效地管理II型错误率,并在徒劳监控期间保持I型错误控制.
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