患有eosinophilic胃肠道疾病的患者自闭症:一个系统性审查与元分析
Rian Vilar Lima1, Maria Carolina Rocha Muniz1, Luana Lima Barroso1
1Department of Medicine, University of Fortaleza, Fortaleza, Ceara, Brazil.
概括
这项研究发现eosinophilic胃肠道疾病 (EGID) 和自闭症谱系障碍 (ASD) 之间存在显著的关联. 分析显示,EGID患者中ASD的患病率为21.59%,这表明EGID应该在ASD患者中考虑,反之亦然.
科学领域:
- 胃肠道学和免疫学
- 神经发育障碍 研究 研究 神经发育障碍
- 流行病学 流行病学
背景情况:
- 越来越多的证据将像自闭症谱系障碍 (ASD) 这样的神经发育障碍与eosinophilic胃肠道障碍 (EGID) 联系起来.
- 自闭症和EGID之间的确切关系和同时发生的患病率仍然不完全理解.
- 研究这种关联对于理解共享的病理生理机制至关重要.
结论:
- 这些发现支持在被诊断为ASD的患者中考虑EGID,反之亦然.
- 缺陷的上皮屏障完整性和潜在的细菌转移可能在相关疾病的发病过程中发挥作用.
- 建议通过多中心前性研究进一步验证这些结果.
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