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1997-2018年接受关节骨折手术的患者使用阿片类药物的时间趋势:一项基于丹麦人口的队列研究

I M Melsen^1,2, S K Szépligeti^1,2, P H Gundtoft^2,3

¹Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

European journal of pain (London, England)

|April 6, 2024

概括

在部骨折手术后的阿片类药物处方在手术后的第一季度显著增加,但整体剂量和长期使用保持稳定. 这凸显了需要小心地逐渐减少阿片类药物和选择更低成潜力的药物.

科学领域:

疼痛管理疼痛管理
老年人手术是一门老年人手术.
药物监督药物监督药物监督

背景情况:

阿片类药物对于管理关节骨折手术后的疼痛至关重要.
之前的研究没有详细说明过去二十年来阿片类药物使用趋势.

研究的目的:

从1997年到2018年,分析关节骨折患者阿片类药物使用的时间趋势.
评估随着时间的推移而发生的阿片类药物流行,剂量和类型的变化.

主要方法:

分析了55岁以上的阿片类药物先验关节骨折患者的基于人口的队列 (n=115,962).
运用阿片类药物的患病率 (PR) 计算了手术后的四季度,跨越两年期间.
估计了流行率比率 (PRR) 和中位数吗啡毫克相当量 (MME),将当前时期与1997-1998年进行比较.

主要成果:

手术后第一季度 (Q1) 的阿片类药物使用率从29% (1997-1998) 增加到78% (2017-2018),增加了2.7倍.
虽然第一季度使用量激增,但第四季度 (第四季度) 的阿片类药物使用量在2017-2018年保持稳定,为13%,而1997-1998年为15%.
在研究期间,中位数吗啡毫克相当量 (MME) 没有增加,主要阿片类药物从特拉马多尔转向氧.

结论:

在部骨折手术后的第一季度,阿片类药物使用率显著增加,但这并没有导致整体剂量增加或手术后长达一年的使用增加.
调查结果强调了针对阿片类药物逐渐减少,适当剂量和使用具有较低成潜力的药物的专注战略的必要性.
对阿片类药物管理的个性化方法,考虑到患者的年龄和特定的术后季度,至关重要.

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