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用PSA,卡利克林面板和MRI进行前列腺癌查:ProScreen随机试验

Anssi Auvinen¹, Teuvo L J Tammela^2,3, Tuomas Mirtti^4,5,6,7,8

¹Tampere University, Unit of Health Sciences, Faculty of Social Sciences, Tampere, Finland.

|April 6, 2024

概括

一个包括PSA检测,4-kallikrein面板和MRI在内的前列腺癌查方案检测到更多的高等级癌症. 这项初步研究表明,在50至63岁的男性中早期发现前列腺癌可能有好处.

科学领域:

泌尿外科
癌症学
公共卫生

背景情况:

前列腺特异性抗原 (PSA) 查可以降低前列腺癌死亡率.
然而,它往往会发现临床上没有意义的癌症,导致过度治疗.
新的查方案旨在改善临床上显著的前列腺癌的检测.

研究的目的:

使用多模式查方案评估低度和高度前列腺癌的检测率.
将被邀请参加查和对照组之间的癌症检测率进行比较.

主要方法:

在ProScreen试验中,超过6万名年龄在50-63岁之间的男性被随机分别邀请进行查或没有邀请.
查方案包括PSA检测,4-卡利克林面板和符合条件的男性MRI.
在受邀和对照组之间比较了癌症发病率.

主要成果:

查邀请组的累积发病率为低度前列腺癌的0. 26%,高度前列腺癌的1. 13%.
对照组的累积发病率为低度前列腺癌的0. 14%和高度前列腺癌的0. 62%.
低度癌症的风险差异为0.11%,高度癌症的风险差异为0.51%.

结论:

与没有查相比,这种多模式查的单一轮检测出每196名男性增加1例高度癌症和每909名男性增加1例低度癌症.
这些是正在进行的试验的初步发现,并应等待初级死亡结果的解释.
这项研究强调了PSA,kallikrein面板和MRI在检测显著前列腺癌方面的潜力.

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