血清TSH度与骨矿物质密度之间的关联:一个综合性审查
Martyna Dziedzic1,2, Michał Bonczar3,4, Patryk Ostrowski3,4
1Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland. martyna.dziedzic30@gmail.com.
Hormones (Athens, Greece)
|April 6, 2024
概括
亚临床甲状腺功能障碍症会降低骨矿物密度 (BMD),增加骨折风险. 降低甲状腺刺激激素 (TSH) 水平可能是骨质损失的独立风险因素,影响男性和女性.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 老年医学 老年医学
背景情况:
- 甲状腺刺激激素 (TSH) 在骨代谢中起着至关重要的作用.
- 亚临床甲状腺功能障碍与各种健康风险有关,包括对骨健康的潜在影响.
- 了解TSH水平与骨矿物质密度 (BMD) 之间的关系对于临床实践至关重要.
研究的目的:
- 综合现有的关于血清TSH度与骨质瘤之间的关联的证据.
- 为临床医生提供有关TSH和骨健康的最新统计见解.
- 评估TSH水平对骨折风险的影响.
主要方法:
- 采用了一种总体审查方法.
- 在主要的医学数据库 (PubMed,科学网,Embase,Scopus,Cochrane图书馆,谷歌学者) 中进行了系统的搜索.
- 包括关于TSH和BMD的元分析和系统审查,随后对初级研究进行统计分析.
主要成果:
- 分析包括了75,898名患者的数据.
- 亚临床甲状腺功能障碍与任何骨折风险增加1.36倍有关 (p < 0.001).
- 在男性患者的远端半径 (SMD = -0.61,p = 0.02) 中,L-甲氧抑制疗法对 BMD 产生了显著的负面影响,并趋向于增加骨折风险 (RR = 1.98,p = 0.06).
结论:
- 亚临床甲状腺功能增强症对骨健康有害,导致骨质量降低和骨折风险增加.
- 血清TSH水平降低可能独立地导致骨质量下降和骨折发生率增加.
- 根据骨部位和患者的人口统计学,TSH抑制治疗对骨硬化的影响有所不同,需要考虑个性化治疗,特别是在DTC后的患者中.
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:18Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
01:31Essential Minerals for Bone Health
3.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.9K
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K