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吸烟和功能障碍的进展:一个纵向队列研究
Ayako Matsumoto1, Yasuyuki Nagasawa2, Ryouhei Yamamoto3,4,5
1Department of General Internal Medicine, Hyogo Medical College, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, Japan.
吸烟显著加快慢性病 (CKD) 的进展,特别是在蛋白尿症患者中. 这项大型研究强调,吸烟是普通人群和慢性病人群中功能障碍的主要危险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
- 心血管疾病研究研究
背景情况:
- 吸烟是心血管疾病 (CVD) 的一个显著可修改的风险因素.
- 吸烟对慢性病 (CKD) 进展的影响以前是不确定的.
- 吸烟和心血管疾病事件之间的确立联系强调了调查其他健康影响的必要性.
研究的目的:
- 调查吸烟对慢性病 (CKD) 进展的影响.
- 检查吸烟和新发蛋白尿对功能下降的综合影响.
- 评估吸烟是日本大量人口中功能障碍的危险因素.
主要方法:
- 在日本年度健康检查计划中,对149,260名参与者 (40-74岁) 的数据进行分析.
- 纵向观察,以评估吸烟状态,新发蛋白尿和估计的淋巴细胞过率 (eGFR) 恶化之间的关系.
- 根据吸烟状况和蛋白尿症对参与者进行分层分组,以比较病预后.
主要成果:
- 在男性中,新发蛋白尿是功能障碍最强的预测因素 (OR 1.41),其次是吸烟 (OR 1.24).
- 在女性中,吸烟是功能障碍最强的预测因素 (OR 1.27),其次是新发蛋白尿 (OR 1.26).
- 蛋白尿和吸烟的组表现出最糟糕的脏预后 (P趋势<0.001).
结论:
- 这项研究表明,吸烟对CKD进展有不利影响.
- 吸烟对功能的负面影响在蛋白尿症和没有蛋白尿症的个体中都很明显.
- 戒烟对于减轻功能下降和预防CKD进展至关重要.
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