双向关系之间的 dipeptidyl 酸酶4 和 血管新生素 II I 型受体信号传递
Flavia L Martins1,2, Joao Carlos Ribeiro-Silva3, Ravi Nistala2
1Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.
American journal of physiology. Cell physiology
|April 6, 2024
概括
双二二酸酶4 (DPP4) 抑制通过降低血管新生素II (Ang II) 水平来缓解心脏代谢疾病. 这种双向关系凸显了DPP4和Ang II作为疾病管理的关键目标.
科学领域:
- 心血管研究研究心血管研究
- 代谢疾病病理生理学 代谢疾病病理生理学
- 在疾病中的酶功能.
背景情况:
- 心脏代谢性疾病与血管新生素II (Ang II) 的升高有关,导致氧化应激,炎症和纤维化.
- 在这些疾病中观察到增加的二二酶4 (DPP4) 活性,其抑制可以减少这些有害影响.
- 在实验模型中,DPP4抑制已被证明可以降低Ang II水平.
研究的目的:
- 在心脏代谢疾病中审查Ang II和DPP4之间交叉交互的证据.
- 探索这种双向监管关系背后的潜在机制.
- 了解Ang II和DPP4如何共同促进疾病的进展.
主要方法:
- 对研究Ang II和DPP之间的相互作用的文献综述4.
- 对实验模型的分析表明DPP4抑制对Ang II的影响.
- 检查关于ACE抑制剂和AT1R抑制剂的研究,涉及DPP4活性.
主要成果:
- 在实验性心脏代谢疾病模型中,DPP4抑制阻止Ang II上调.
- ACE 抑制剂和 AT1R 阻断剂降低了 DPP4 的活性,表明了双向的联系.
- 有证据支持Ang II和DPP4路径之间的跨调节相互作用.
结论:
- 在心脏代谢疾病的背景下,Ang II和DPP4之间存在显著的交叉.
- 了解这种双向关系对于开发新型治疗策略至关重要.
- 针对DPP4和Ang II通路可能为管理心脏代谢疾病提供协同效益.
相关概念视频
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
720
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
720
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
627
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
627
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.5K
01:25Antihypertensive Drugs: Direct Renin Inhibitors
613
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
613
01:23Dipeptidyl Peptidase 4 Inhibitors
182
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
182
01:45Endocrine Signaling
64.3K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.3K