一个由血代谢产生的通用签名预测了MAFLD中心血管疾病风险
Zhonglin Li1, Rui Gong2, Huikuan Chu1
1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Atherosclerosis
|April 6, 2024
概括
患有心血管疾病 (CVD) 风险的代谢相关脂肪肝 (MAFLD) 患者表现出明显的肠道微生物和代谢物. 使用代谢物和临床数据的预测模型可以识别MAFLD患者的早期心血管疾病风险.
科学领域:
- 胃肠病学和肝病学
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是疾病进展和肝外并发症,特别是心血管疾病 (CVD) 的关键因素.
- 在MAFLD患者中早期预测心血管疾病风险至关重要,因为当前的方法,如动脉超声波检测已建立的病理损伤.
- 在发生重大病理变化之前,需要方法来预测MAFLD中心血管疾病风险.
研究的目的:
- 为了确定与心血管疾病 (CVD) 风险相关的肠道微生物组和血代谢物签名的歧视性肠道微生物组和血代谢物签名,在患有代谢相关脂肪肝疾病 (MAFLD) 的患者中.
- 开发使用已识别的生物标志物和临床参数的MAFLD患者心血管疾病风险的早期预测模型.
主要方法:
- 对196名参与者的便微生物组 (16S rDNA测序) 和血代谢概况进行比较分析 (对照组,简单的MAFLD,带有冠状动脉变化的MAFLD,带有CAD的MAFLD).
- 利用差异丰度分析和随机森林机器学习来识别歧视性微生物和代谢标记.
- 开发并验证了一种结合代谢物特征与9个临床参数的预测模型.
主要成果:
- 患有心血管疾病风险的MAFLD患者表现出改变的肠道微生物群,包括增加的Clostridia和更高的Firmicutes-to-Bacteroidetes比率.
- 特定的微生物物种 (例如,Faecalibacterium,Megamonas,Bacteroides) 和血代谢物 (例如,Citral,Biotin l-sulfoxide) 与心血管疾病风险标志物和病理变化相关.
- 整合代谢物特征和9个临床参数的预测模型在发现和验证队列中准确区分了患有心血管疾病风险的MAFLD患者,其中醇被确定为关键代谢物.
结论:
- 在简单的MAFLD患者和心血管疾病风险患者之间,肠道微生物组和血代谢物概况显著不同.
- 开发的基于代谢物和临床参数的预测模型提供了有效的早期对MAFLD患者心血管疾病风险的歧视.
- 这种方法有望为高风险心血管并发症的MAFLD患者的积极管理和干预提供希望.
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