女性性激素对主动行为和生理免疫参数的影响
Judith K Keller1, Esther K Diekhof1
1Neuroendocrinology and Human Biology Unit, Department of Biology, Faculty of Mathematics, Informatics and Natural Sciences, Institute for Animal Cell- and Systems Biology, Universität Hamburg, Hamburg, Germany.
Reproductive biology
|April 6, 2024
概括
尽管有理论预测,但女性在黄体阶段不会表现出增加的厌恶或免疫反应. 孕激素水平与增加的疾病回避或分泌IgA (sIgA) 反应无关.
科学领域:
- 生殖免疫学 生殖免疫学
- 行为内分泌学行为内分泌学.
- 易受感染性疾病的易感性
背景情况:
- 由于孕激素的免疫抑制作用,女性在黄体期可能更容易感染感染.
- 这种免疫抑制,虽然有助于怀孕,但可能会增加对病原体的脆弱性.
- 理论上的补偿机制包括增加的厌恶和回避行为,以及像分泌IgA (sIgA) 这样的免疫反应.
研究的目的:
- 调查在不同月经周期阶段和使用荷尔蒙避孕的妇女对疾病线索的主动免疫和行为反应.
- 为了确定孕激素诱导的免疫抑制是否被增加的厌恶或sIgA水平所抵消.
主要方法:
- 对比的是61名具有自然月经周期的妇女 (卵泡相对于质阶段) 和20名服用荷尔蒙避孕药的妇女.
- 评估疾病脆弱性,厌恶和对与疾病相关的视频刺激的反应.
- 测量了唾液激素水平和分泌IgA (sIgA) 度.
主要成果:
- 在HC的女性报告了比自然骑自行车的女性更高的疾病脆弱性.
- 对疾病线索的厌恶和sIgA反应在不同组中是相似的,不管孕激素水平如何.
- 在自然循环女性中,在孕激素和基线sIgA之间观察到U形关系,在排卵期间出现下降.
结论:
- 数据不支持孕激素诱导的免疫抑制和增强的厌恶或主动的sIgA反应之间的补偿关系.
- 荷尔蒙避孕药,而不是黄体期的孕激素,与感知到疾病脆弱性的增加有关.
- 对疾病线索的积极免疫和行为反应似乎独立于黄质阶段的孕激素水平.
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