暴露会通过降低甲状腺激素受体/PGC1α信号来激活 mitophagy 在孕前

Zhen Yu1, Tao Yu1, Xuan Li1

  • 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Key Laboratory of Population Health Across Life Cycle, Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Provincial Institute of Translational Medicin (Anhui Medical University), No. 81 Meishan Road, Hefei, Anhui 230032, China.

概括

孕产妇暴露于会激活胎盘线粒,这是一种与孕前相关的过程. 这通过降低PGC1α表达发生,影响线粒体功能并增加可溶性Flt1 (sFlt1) 水平,从而导致先兆子的发展.

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